Rapamycin-induced phosphaturia

Rapamycin-induced phosphaturia.

BACKGROUND The mammalian target of rapamycin (mTOR) is known to stimulate a variety of transport mechanisms including the intestinal phosphate transporter NaPi-IIb. The present study was performed to elucidate whether mTOR similarly regulates the major renal tubular phosphate transporter NaPi-IIa. METHODS To this end, NaPi-IIa was expressed in Xenopus oocytes with or without mTOR and phosphat...

[Clinical significance of phosphaturia].

From September 1986 to August 1987, heavy precipitation of amorphous calcium phosphate, that is phosphaturia, was found at our outpatient clinic in 153 postprandial urine specimens from 115 patients, in 1.5% of all the specimens examined during this period. One patient was excluded because he had both urolithiasis and urinary tract infection. The remaining 152 specimens with phosphaturia were t...

Phosphaturia in magnesium-deficient rats.

GINN, H. EARL, AND LINDA L. SHANBOUR. Phosphaturia in magnesium-dejcient rats. Am. J. Physiol. 2 12(6) : 1347-1350. rg67.-The effect of magnesium deficiency on urinary phosphate excretion was studied in rats rendered magnesium deficient by diet. Increased urinary phosphate excretion was observed. Tubular maximum reabsorption (Tm) of inorganic phosphate was lower in magnesium-deficient (0.9 =t 0...

A Case of Alternating Oxaluria and Phosphaturia

Rapamycin inhibits GM-CSF-induced neutrophil migration.

The molecular mechanisms that govern cell movement are the subject of intense study, as they impact biologically and medically important processes such as leukocyte chemotaxis and angiogenesis, among others. We demonstrate that leukocyte chemotaxis is prevented by the macrolide immunosuppressant rapamycin, a specific inhibitor of the mammalian target of rapamycin (mTOR)/ribosomal p70-S6 kinase ...